A petrochemical enterprise in Shandong province has been selected as the research object. A model of groundwater flow and solute transport has been constructed by using GMS to simulate the pollution distribution of typical pollutants in petrochemical enterprises under normal seepage and seepage prevention. It is showed that the contaminated plume diffuses horizontally along with the flow direction under normal seepage condition. The diffusion range will expand with the increase of time, and the maximum migration distance is 26.15 m when the simulated time is 9500d. The contaminated plume migrates slowly in vertical direction due to the influence of soil permeability. The maximum concentration in the bottom clay layer is 0.074mg/L when the simulation time is 9500d. The transverse migration of pollution plume is obviously limited, but the vertical migration will increase when cut-off wall is adopted in the downstream of pollution source. The maximum migration distance is 23.65m when the simulation time is 9500d. Comparing with normal seepage, the longitudinal migration of the pollution plume will enhance. The concentration of the clay layer at the bottom will increases obviously after the barrier wall is set up. The concentration can reach 0.152mg/L, which is the maximum at 9500d.