According to the extraction of alteration anomaly information from remote sensing images in Sinkat mining area in Red Sea State of Sudan, three iron-stained alteration anomaly areas, three hydroxyl-stained alteration anomaly areas and one overlapping area of iron-stained and hydroxyl-stained alteration anomalies have been delineated. Geological mapping, trench exploration and civil mining engineering cleaning have been carried out, and 8 mineralized alteration zones and 23 mineralized bodies have been delineated. Good prospecting results have been achieved. In this paper, the type of ore deposits in Sinkat mining area is orogenic gold deposits. Geological and remote sensing prospecting indicators have been summarized, and the prospecting prospects have been put forward. The prospecting model of "remote sensing+geology" has been put forward. It has a good demonstration role in prospecting in Red Sea State of Sudan.