Abstract:High content of fluoride and mineralization in groundwater is a common problem in southwestern Shandong province. Resistivity is closely related to the mineralization of groundwater, and high fluorine is easy to coexist with high mineralization. Therefore, the difference in electrical properties between clay layer with high mineralized groundwater and sandy layer with potable can provide basic condition for exploring potable groundwater in this area by using electrical method. Based on regional geology, hydrogeology and geophysical characteristics, the electric sounding curves in key areas are interpreted qualitatively and quantitatively in detail, and the buried depth of aquifers, clay layer and sand layer boundary in key areas are divided. It is inferred that the deep high resistivity layer is mainly fresh water sandy layer. According to the results of geophysical prospecting, two drilling holes are constructed in Shatuji town in Mudan district and Changleji town in Caoxian county. It is showed that the drilling water output is abundant and the water quality is significantly improved compared with the surrounding areas. Direct current resistivity sounding is an economic and effective exploration method for searching for potable water resources in this area.