Abstract:The development of mineral resources has caused the groundwater imbalance, and groundwater imbalance has caused great trouble in mineral resources exploration. In recent years, the contradiction between the exploitation of mineral resources and groundwater environmental protection is more and more evident. Through analysis and study on typical hydrogeological conditions of Luxin well in Inner Mongolia, groundwater imbalance mechanism caused by mining has been analyzed, the effect of water filling conditions in exploration and development of mines to groundwater environment has been studied, reasonable countermeasures have been put forward to promote mutual coordination between mineral resources exploitation and protection of groundwater, and provide basic geological basis for achieving the harmony of "mining and water protection". It will provide some references for following the laws of nature, the process of mineral development in similar areas, developing the advantages and avoiding disadvantages, ensuring production safety, protection of groundwater environmental security, and realizing green developement resources.