VSHMS type deposit is a new trend for researching massive sulfide deposits in recent years. Adidesta deposit in northern Ethiopia is a large VSHMS type copper-zinc polymetallic deposit with the characteristics of variant symbiosis and associated silver. Through study on regional geological background, geology, geological characteristics of the deposit, it is pointed out that the ore-bearing strata of copper-zinc deposit are Proterozoic Teshalite metamorphic volcanic sedimentary rock group. The ore belt has the "color alteration zone" characteristics. Comparing with typical VSHMS deposits, genesis type and metallogenic model of the deposit are preliminaryly studied.