In order to know the health risk of Dongping Lake, samples have been obtained from the lake during dry and wet seasons. Concentrations of eight compounds related to health risk have been analyzed. National standards and the health risk assessment model have been utilized to evaluate its water environment and health risk. It is showed that the overall water quality of Dongping Lake is good and concentrations of eight targeted compounds almost all meet class Ⅰ standard of environmental quality standards for surface water and standards for drinking water quality. The health risk of cancinogenic chromium is high up to 2.92×10-4a-1 , more than the maximum acceptable level of 1×10-4a-1 recommended by USEPA and the health risk of non-carcinogenic substances was low to about 10-11~10-9a-1. It is suggested that the discharge of chromium-containing waste water should be controlled in future.