During the coal mining process of No.16 coal seam of Binhu coal mine, water irruption has repeatedly happened and affected the normal production of mine. Through analysis on water filling conditions of No.16 coal seam, various causes of flood threat can be found and reasonable and effective prevention countermeasures can be made in order to ensure the safety of No.16 coal seam in Binhu coal mine. It will provide some references for mining No.16 coal seam in other coal mines.