Abstract:The downstream region of the Yellow River in Shandong province is serious illness area of endemic fluorosis. On the basis of regional surveying, choosing 4 typical counties as studying areas, such as Yuncheng, Jiaxiang, Dongchangfu and Boxing county, the indexs of iodin content in soil, drinking water, iodin content in emiction and hypothyroid cubage and the ratio of goitre from children are studied. As showed by the results, it is indicated that the iodin content is universal higher in drinking water and emiction, the harm of high iodin and the endemic goitre due to high iodin are serious. On the basis of analyzing the distribution and the change law of iodin in soil and drinking water, the correlation between high iodin endemic goitre and geochemical environment are studied. It is showed that high iodin endemic goitre has positive correlation with iodin in drinking water, but it does not have obvious correlation with iodin in soil.