Through laboratory study on new flotation technology without fluorite to purify quartz sand in Gambia, major mineral combinations and compositions are grasped, and pre-sizing-flotation in second step is determined to be a good technology in purifing this kind of quartz sand. S?H?N and B?C?A are regarded as best collector to seperate quartz and feldspar from iron-bearing minerals. Through laboratory of multi-element flotation in large scope and analysis in small scope, good quartz sand flotation technology and flotation quota are determined finally.